Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations
This paper examined changes in ~5000 plasma proteins in response to exercise training and found hundreds of proteins modulated. We highlight proteins involved in angiogenesis, iron homeostasis, and the extracellular matrix, many of which are novel, including training-induced increases in fibroblast activation protein (FAP), a membrane-bound and circulating protein relevant in body-composition homeostasis. We relate protein changes to training-induced maximal oxygen uptake adaptations and validate our top findings in an external exercise cohort. Furthermore, we show that FAP is positively associated with survival in 3 separate, population-based cohorts
Citation: Robbins JM, Rao P, Deng S, Keyes M, Tahir U, Katz D, Beltran P, Marchildon F, Barber JL, Peterson B, Gao Y, Correa A, Wilson J, Smith JG, Cohen P, Bouchard C, Sarzynski MA, Gerszten RE. Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations. JCI Insight 2023; 8(7):e165867. PMID: 37036009 PMCID: PMC10132160 https://doi.org/10.1172/jci.insight.165867
